Publications

Representative publications:

Modulating EGFR-MTORC1-autophagy as a Potential Therapy for Persistent Fetal Vasculature (PFV) Disease.

Yazdankhah M, Shang P, Ghosh S, Bhutto IA, Stepicheva N, Grebe R, Hose S, Weiss J, Luo T, Mishra S, Riazuddin SA, Ghosh A, Handa JT, Lutty GA, Zigler  JS Jr, Sinha D.

Autophagy. 2020 Jun;16(6):1130-1142. doi: 10.1080/15548627.2019.1660545.

Neutrophils Homing Into the Retina Trigger Pathology in Early Age-Related Macular Degeneration.

Ghosh S, Padmanabhan A, Vaidya T, Watson AM, Bhutto IA, Hose S, Shang P, Stepicheva N, Yazdankhah M, Weiss J, Das M, Gopikrishna S, Aishwarya, Yadav N, Berger T, Mak TW, Xia S, Qian J, Lutty GA, Jayagopal A, Zigler JS Jr, Sethu S, Handa JT, Watkins SC, Ghosh A, Sinha D.

Commun Biol. 2019 Sep 20;2:348. doi: 10.1038/s42003-019-0588-y.

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration.

Ghosh S, Shang P, Terasaki H, Stepicheva N, Hose S, Yazdankhah M, Weiss J, Sakamoto T, Bhutto IA, Xia S, Zigler JS Jr, Kannan R, Qian J, Handa JT, Sinha D.

Invest Ophthalmol Vis Sci. 2018 Mar 20;59(4):AMD104-AMD113. doi: 10.1167/iovs.18-24132.

ATAC-Seq Analysis Reveals a Widespread Decrease of Chromatin Accessibility in Age-Related Macular Degeneration.

Wang J, Zibetti C, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S, Ji H, Merbs SL, Zack DJ, Handa JT,   Sinha D, Blackshaw S, Qian J

Nat Commun. 2018 Apr 10;9(1):1364. doi: 10.1038/s41467-018-03856-y.

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin,   complex 1 signaling.

Shang P, Valapala M, Grebe R, Hose S, Ghosh S, Bhutto IA, Handa JT, Lutty GA, Lu L, Wan J, Qian J, Sergeev Y, Puertollano R, Zigler JS Jr, Xu GT, Sinha D.

Aging Cell. 2017 Apr;16(2):349-359. doi: 10.1111/acel.12561.

Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration.

Ghosh S, Shang P, Yazdankhah M, Bhutto I, Hose S, Montezuma SR, Luo T, Chattopadhyay S, Qian J, Lutty GA, Ferrington DA, Zigler JS Jr, Sinha D.

J Pathol. 2017 Apr;241(5):583-588. doi: 10.1002/path.4870.

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response.

Valapala M, Edwards M, Hose S, Grebe R, Bhutto IA, Cano M, Berger T, Mak TW, Wawrousek E, Handa JT, Lutty GA, Samuel Zigler J Jr, Sinha D.

Aging Cell. 2014 Dec;13(6):1091-4. doi: 10.1111/acel.12274.

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.

Valapala M, Wilson C, Hose S, Bhutto IA, Grebe R, Dong A, Greenbaum S, Gu L, Sengupta S, Cano M, Hackett S, Xu G, Lutty GA, Dong L, Sergeev Y, Handa JT, Campochiaro P, Wawrousek E, Zigler JS Jr, Sinha D.

Autophagy. 2014 Mar;10(3):480-96. doi: 10.4161/auto.27292.

Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes.

Valapala M, Hose S, Gongora C, Dong L, Wawrousek EF, Samuel Zigler J Jr, Sinha D.

Nat Commun. 2013;4:1629. doi: 10.1038/ncomms2624.

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat.

Zigler JS Jr, Zhang C, Grebe R, Sehrawat G, Hackler L Jr, Adhya S, Hose S, McLeod DS, Bhutto I, Barbour W, Parthasarathy G, Zack DJ, Sergeev Y, Lutty GA, Handa JT, Sinha D.

J Cell Sci. 2011 Feb 15;124(Pt 4):523-31. doi: 10.1242/jcs.078790.

Further reading:

Role of glia in optic nerve.

Yazdankhah M, Shang P, Ghosh S, Hose S, Liu H, Weiss J, Fitting CS, Bhutto IA, Zigler JS Jr, Qian J, Sahel J-A, Sinha D, Stepicheva NA.

Prog Retin Eye Res. 2020 Aug 6;100886. doi: 10.1016/j.preteyeres.2020.100886.

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.

Kaarniranta K, Uusitalo H, Blasiak J, Felszeghy S, Kannan R, Kauppinen A, Salminen A, Sinha D, Ferrington D.

Prog Retin Eye Res. 2020 Apr 13;100858. doi: 10.1016/j.preteyeres.2020.100858.

The Role of lipocalin-2 in Age-Related Macular Degeneration (AMD).

Ghosh S, Stepicheva N, Yazdankhah M, Shang P, Watson AM, Hose S, Liu H, Weiss J, Zigler JS Jr, Valapala M, Watkins SC, Sinha D.

Cell Mol Life Sci. 2020 Mar;77(5):835-851. doi: 10.1007/s00018-019-03423-8.

Melatonin as the Possible Link Between Age-Related Retinal Regeneration and the Disrupted Circadian Rhythm in Elderly.

Stepicheva NA, Weiss J, Shang P, Yazdankhah M, Ghosh S, Bhutto IA, Hose S, Zigler JS Jr, Sinha D.

Adv Exp Med Biol. 2019;1185:45-49. doi: 10.1007/978-3-030-27378-1_8.

Primary Cell Cultures from the Mouse Retinal Pigment Epithelium.

Shang P, Stepicheva NA, Hose S, Zigler JS Jr, Sinha D.

J Vis Exp. 2018 Mar 16;(133). doi: 10.3791/56997.

A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems.

Zigler JS Jr, Hodgkinson CA, Wright M, Klise A, Sundin O, Broman KW, Hejtmancik F, Huang H, Patek B, Sergeev Y, Hose S, Brayton C, Xaiodong J, Vasquez D, Maragakis N, Mori S, Goldman D, Hoke A, Sinha D.

PLoS One. 2016 Jul 29;11(7):e0160447. doi: 10.1371/journal.pone.0160447. 

Modulation of V-ATPase by βA3/A1-Crystallin in Retinal Pigment Epithelial Cells.

Valapala M, Sergeev Y, Wawrousek E, Hose S, Zigler JS Jr, Sinha D.

Adv Exp Med Biol. 2016;854:779-84. doi: 10.1007/978-3-319-17121-0_104.

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium.

Sinha D, Valapala M, Shang P, Hose S, Grebe R, Lutty GA, Zigler JS Jr, Kaarniranta K, Handa JT.

Exp Eye Res. 2016 Mar;144:46-53. doi: 10.1016/j.exer.2015.08.018.

βA3/A1-crystallin and persistent fetal vasculature (PFV) disease of the eye.

Zigler JS Jr, Valapala M, Shang P, Hose S, Goldberg MF, Sinha D.

Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):287-98. doi: 10.1016/j.bbagen.2015.05.017.

βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.

Valapala M, Edwards M, Hose S, Hu J, Wawrousek E, Lutty GA, Zigler JS Jr, Qian J, Sinha D.

Sci Rep. 2015 Mar 4;5:8755. doi: 10.1038/srep08755.

Expression pattern of an evolutionarily conserved splice variant in the rat Tacc2 gene.

Padhi BK, Zigler JS Jr, Padhi P, Hose S, Sinha D.

Genesis. 2014 May;52(5):378-86. doi: 10.1002/dvg.22776.

βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina.

Sinha D, Valapala M, Bhutto I, Patek B, Zhang C, Hose S, Yang F, Cano M, Stark WJ, Lutty GA, Zigler JS, Wawrousek EF.

Transgenic Res. 2012 Oct;21(5):1033-42. doi: 10.1007/s11248-012-9608-0.

βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis.

Ma B, Sen T, Asnaghi L, Valapala M, Yang F, Hose S, McLeod DS, Lu Y, Eberhart C, Zigler JS Jr, Sinha D.

Cell Death Dis. 2011 Oct 13;2:e217. doi: 10.1038/cddis.2011.100.

A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye.

Zhang C, Asnaghi L, Gongora C, Patek B, Hose S, Ma B, Fard MA, Brako L, Singh K, Goldberg MF, Handa JT, Lo WK, Eberhart CG, Zigler JS Jr, Sinha D.

Eur J Cell Biol. 2011 May;90(5):440-8. doi: 10.1016/j.ejcb.2011.01.003.

betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development.

Sinha D, Klise A, Sergeev Y, Hose S, Bhutto IA, Hackler L Jr, Malpic-Llanos T, Samtani S, Grebe R, Goldberg MF, Hejtmancik JF, Nath A, Zack DJ, Fariss RN, McLeod DS, Sundin O, Broman KW, Lutty GA, Zigler JS Jr.

Mol Cell Neurosci. 2008 Jan;37(1):85-95.

Developmental abnormalities in the Nuc1 rat retina: a spontaneous mutation that affects neuronal and vascular remodeling and retinal function.

Gehlbach P, Hose S, Lei B, Zhang C, Cano M, Arora M, Neal R, Barnstable C, Goldberg MF, Zigler JS Jr, Sinha D.

Neuroscience. 2006;137(2):447-61. 

A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye.

Zhang C, Gehlbach P, Gongora C, Cano M, Fariss R, Hose S, Nath A, Green WR, Goldberg MF, Zigler JS Jr, Sinha D.

Dev Dyn. 2005 Sep;234(1):36-47.

A spontaneous mutation affects programmed cell death during development of the rat eye.

Sinha D, Hose S, Zhang C, Neal R, Ghosh M, O'Brien TP, Sundin O, Goldberg MF, Robison WG Jr, Russell P, Lo WK, Samuel Zigler J Jr.

Exp Eye Res. 2005 Mar;80(3):323-35.

A novel rat model to study the functions of macrophages during normal development and pathophysiology of the eye.

Hose S, Zigler JS Jr, Sinha D.

Immunol Lett. 2005 Jan 31;96(2):299-302.

Complete List of Debasish Sinha's published work:

© 2020 by Debasish Sinha Research Lab.