Debasish Sinha
Laboratory
Department of Ophthalmology,
University of Pittsburgh,
School of Medicine
Our laboratory is interested in understanding the role of glia and glia-like cells (retinal pigmented epithelium) in ocular health and disease. We use genetically engineered mouse and spontaneous mutant rat models as tools to decipher functions of these cells in health and disease. The diseases we focus on are (1) Age-related Macular Degeneration (AMD) (2) Diabetic Retinopathy (DR) and (3) Persistent Fetal Vasculature (PFV).
Video:
Ribbon scanning confocal microscopy image acquisition along with 3-D rendering of gross whole eye morphology and cross-sectional image acquisition showing infiltrating of neutrophils in the retina and Schlemm's canal (a channel at the limbus, which is the joining point of the cornea and sclera, encircling the cornea) among intravenously injected immunocompromised mice treated with IFNlambda-exposed Wild type neutrophils.
