• Nadezda .Stepicheva


Updated: Jun 2

The last couple of years have been tough, but our dream team worked very hard to be represented at ARVO-2022 that took place in Denver, Colorado. And this year we had a record number of presentations from our lab, including 4 talks and 8 posters!

The presentations are available online, at ARVO website and app through June 30, so feel free to have a peak at our work if you have registered for ARVO ! Sunday, May 1st

12:15pm-2:15pm Poster Session: Vascular Biology,

Board #F0311: “The differential role of distinct astrocyte populations in Persistent Fetal Vasculature (PFV) disease” (Victoria Koontz’s poster):

2:45pm-4:45pm Paper Session: Molecular events in diabetic retinopathy,

3:53pm-4:10pm: “The Role of the STING/Type I IFN Signaling Pathway in Diabetic Retinopathy” (Haitao Liu’s talk):

Tuesday, May 3rd

8-10am Symposium: Autophagosomes, lysosomes and other -somes: their role in ocular tissues homeostasis,

9:22-9:41am: “Rejuvenating lysosome/autophagy function in the RPE as a possible therapeutic strategy for dry AMD” (Debasish Sinha’s talk):

10:30am-12:30pm Poster Session: Retinal metabolism and physiology,

Board #F0180: “PITPb/bA3/A1-crystallin complex is critical for PIP metabolism in retinal pigment epithelium (RPE)” (Emma Mahally’s poster):

Paper Session: Lens proteins: normal and pathogenic biochemistry,

11:04am-11:21am: “Looking for hidden cues: can the function of the moonlighting ocular protein bA3/A1-crystallin be regulated by the signals hidden in its coding sequence?” (Nadia Stepicheva’s talk):

1-3pm Poster Session: RPE/choroid pathology: oxidative stress, inflammation and neovascularization,

Board #F0404: “Activation of mTOR signaling in the RPE cells induces alterations in melanogenesis thereby triggering oxidative stress” (Olivia Chowdhury’s poster):

Board #F0409: “Inhibiting mTOR-independent TFEB activity in RPE alleviates the early AMD-like phenotype in a mouse model” (Mihir Nemani’s poster):

3:30-5:15pm Mini-Symposium: Modulation of the RPE’s immunogenic phenotype in disease,

3:50-4:07pm: “IFNl secreted by the RPE elicits homing of immune cells into the retina during atrophic AMD” (Debasish Sinha’s talk):

Wednesday, May 4th

10am-12pm Poster Session: Biochemistry and Molecular Mechanisms of Diabetic Retinopathy,

Board #A0054: “Akt2 signaling in diabetes-induced dysfunction of the outer blood retina barrier” (Rachel Daley’s poster):

12:30-2:30pm Poster Session: Novel animal models and neuroprotection in the retina, Board #F0352: “HDAC11 is a crucial regulator for visual cycle genes and retinal function” (Peng Shang’s poster):

3-5pm Poster Session: Pathobiology of AMD,

Board #F0394: Lipocalin-2 homodimer variant: Role in dry age-related macular degeneration (Urvi Gupta’s poster):

Board #F0417: “Crosstalk between metabolism and inflammation in dry age-related macular degeneration” (Sayan Ghosh’s poster):

It was so great to be attending an in-person conference again!!! Here are some pictures highlighting our time in Denver:

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